Nucleosides with 5′‐Fixed Lipid Groups – Synthesis and Anchoring in Lipid Membranes

Abstract

Abstract Nucleosides were synthesized bearing one or two lipophilic groups at the 5′‐position. The lipophilic substituents can be fixed at a 5′‐amino group or at the 5′‐phosphate moiety. Selected examples of these lipophilic nucleosides are shown by solid‐state NMR spectroscopy to anchor in lipid double layers. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)