Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

Benjamin P. Lewis, Richard E. Green, Steven E. Brenner · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast

Krishnamurthy Natarajan, Michael R. Meyer, Belinda M. Jackson et al. · Molecular and Cellular Biology · 2001 · 759 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

James S. Hardwick, Finny G. Kuruvilla, Jeffrey K. Tong et al. · Proceedings of the National Academy of Sciences · 1999 · 520 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

Peter Leeds, Stuart W. Peltz, Allan Jacobson et al. · Genes & Development · 1991 · 502 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations

Ken Inoue, Mehrdad Khajavi, Tomoko Ohyama et al. · Nature Genetics · 2004 · 421 citations

Life Sciences, Genetics, Molecular Genetics +16