Concepedia

Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI‐937, CI‐941, and piroxantrone hydrochloride

V. G. BEYLIN, Norman L. Colbry, O. P. Goel, Jerome E. Haky, Donald R. Johnson, Judith L. Johnson, Gerald D. Kanter, Robert L. Leeds, Boguslawa Leja, Edward Lewis,

Journal of Heterocyclic Chemistry · 1989 · 17 citations · 12 references

DOI

Concepts

Abstract

Abstract Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI‐937, CI‐941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of the synthetic sequences.

References

12

Anti-Cancer Drug Design

Michael W. Moore · British Journal of Cancer · 1985 · 398 citations · Full text

Evaluation of a Simple HPLC Correlation Method for the Estimation of the Octanol-Water Partition Coefficients of Organic Compounds

Jerome E. Haky, Anna Young · Journal of Liquid Chromatography · 1984 · 111 citations

, , +16

Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

H. D. Hollis Showalter, Judith L. Johnson, Jeanne M. Hoftiezer et al. · Journal of Medicinal Chemistry · 1987 · 99 citations

, , +8

Anthrapyrazoles, a new class of intercalating agents with high-level, broad spectrum activity against murine tumors.

Wilbur R. Leopold, James M. Nelson, Jacqueline Plowman et al. · PubMed · 1985 · 86 citations

, , +11

A Low Pressure Process for the Reduction of Nitriles. Use of Rhodium Catalyst<sup>1</sup>

Morris Freifelder · Journal of the American Chemical Society · 1960 · 72 citations

, , +11