Concepedia

Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library

Kazuyuki Sagi, Koichi Fujita, Masayuki Sugiki, Mitsuo Takahashi, Shunji Takehana, Kazumi Tashiro, Takashi Kayahara, Masahiro Yamanashi, Yumiko Fukuda, Seiji Oono,

Bioorganic & Medicinal Chemistry · 2005 · 13 citations · 17 references

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References

17

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.

Wolfram Bode, Irmgard Mayr, Ulrich Baumann et al. · The EMBO Journal · 1989 · 893 citations · Full text

, , +6

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

David W. Banner, A. D’Arcy, C. Chene et al. · Nature · 1996 · 733 citations

, , +15

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors

Markus Marquart, J. Walter, J. Deisenhofer et al. · Acta Crystallographica Section B Structural Science · 1983 · 583 citations

, , +13

Structure of Human Des(1-45) Factor Xa at 2·2 Å Resolution

K. Padmanabhan, K. Padmanabhan, A. Tulinsky et al. · Journal of Molecular Biology · 1993 · 392 citations

, , +13