Planta Medica · 2005 · 22 citations · 0 references
PharmacyBotanyMedicinal ChemistryCancer PharmacologyDrug DiscoveryStructure-activity RelationshipsAromatic PlantsMedicinal Plant KnowledgeMedicinal PlantsOncology PharmacologyStructure-activity Relationship AnalysisAnticancer ActivityAnticancer Natural ProductsChemical Structure-activity RelationshipsMedicinal Plant ResourcesPharmacological Screening
Two new triterpenes, 22-angeloyl-21-epoxyangeloylbarringtogenol C (1) and 21,22-diangeloyl-24-hydroxy-R(1)-barrigenol (2), and the known 21,22-diangeloyl-R(1)-barrigenol (3) were isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on detailed NMR analysis. Compounds 1 and 2 inhibited significantly the growth of cancer cell lines (A375-S2, HeLa) with IC(50) values ranging from 2.9 to 76.3 micromol/L.