Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

Haitao Zhu, Dongqing Wang, Yanfang Liu, +8

Cancer Cell International

MitophagyBiological MicroenvironmentsCancer BiologyTumor BiologyCell Autophagy +17

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

Xiujian Xu, Liang Zhang, Xinchun Ye, +4

Inflammation Research

InflammationCerebral Vascular RegulationCerebral Ischemia ReperfusionMedicineImmunology +13

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

Xinchun Ye, Tong Shen, Jinxia Hu, +15

Experimental Neurology

ApoptosisCell DeathCerebral Vascular RegulationAutophagyBrain Injury +15

Glucocorticoid regulation of a novel HPV–E6–p53– <b> <i>miR‐145</i> </b> pathway modulates invasion and therapy resistance of cervical cancer cells

Ming Shi, Libin Du, Dan Liu, +11

The Journal of Pathology

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Yingcai Wang, Jiwen Liu, Paul J. Dransfield, +27

ACS Medicinal Chemistry Letters

Combinatorial ChemistryMolecular PhysiologyBiochemistryFunctional SelectivityMedicine +11

Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson’s disease patients

Siyuan Chen, Yueqin Liu, Yuanyuan Niu, +5

Neuroscience Letters

Neurodegenerative DiseasesAutoimmune DiseaseImmunologyMyeloid-derived Suppressor CellsPathology +6

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice

Devon Ryan, Kristin S. Henzel, Brandon L. Pearson, +28

Molecular Psychiatry

Ghrelin administration enhances neurogenesis but impairs spatial learning and memory in adult mice

Ziwei Zhao, Huiying Liu, Kewei Xiao, +6

Neuroscience

Developmental BiologySpatial LearningBehavioral NeuroscienceDevelopmental Cognitive NeurosciencePhysiology +9

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes

Narihiro Toda, Xiaolin Hao, Yasuyuki Ogawa, +25

ACS Medicinal Chemistry Letters

Insulin SignalingMetabolic SyndromeMolecular PharmacologyInsulin DeliveryHealth Sciences +14