Antibody‐dependent Lymphocyte‐mediated Cytotoxicity in Man: No Requirement for Lymphocytes with Membrane‐bound Immunoglobulin

Abstract

Normal human lymphocytes, depleted of B‐lymphocytes by passage through nylon‐wool columns, manifested intact antibody‐dependent cell‐mediated cytotoxicity. Similar findings were made with lymphocytes from four hypo‐gammaglobulinaemic patients lacking B‐lymphocytes. It is concluded that antibody‐induced cell‐mediated cytotoxicity in man is independent of B‐lymphocytes, as identifiable by membrane‐bound immunoglobulin.