Science · 1965 · 36 citations · 12 references
MedicineBiochemistryPathologyClinical BiochemistryHepatologyNutritional BiochemistryCholestatic Liver InjuryCirrhosisHepatic ImpairmentHepatic PathologyLiver DiseaseLiver PhysiologyBile Acid-induced CholestasisCholestatic JaundiceJaundice PathogenesisSerum Bile Acid
Lithocholic acid was present in the serum of three patients with, jaundice and, in smaller amounts, in two healthy adults. This bile acid occurs naturally in human feces but induces cirrhosis of the liver when fed to a wide variety of experimental animals. The finding of lithocholic acid in blood is of interest because of its possible role in injuring human liver.
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Measurement of human serum bile acids by gas–liquid chromatography
Douglas H. Sandberg, Jan Sjövall, K. Sjövall et al. · Journal of Lipid Research · 1965 · 279 citations · Full text
Paul J. Thomas, S.L. Hsia, John T. Matschiner et al. · Journal of Biological Chemistry · 1964 · 60 citations · Full text
Qualitative Analysis of Bile Acids by Gas Chromatography. Bile Acids and Steroids. 124.
Jan Sjövall, Anders Kallner, R. J. Bridgwater et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1962 · 52 citations · Full text