Eco-Friendly Microwave-Assisted Scaleable Synthesis of 2-Cyanobenzothiazoles via<b><i>N</i></b>-Arylimino-1,2,3-dithiazoles

Abstract

Abstract The cyclization procedure of N-aryl iminodithiazoles into 2-cyanobenzothiazoles was re-investigated with the aim to develop original and environmentally friendly procedures. In this article, the benefits associated with the microwave methodology are reported and the opportunity to use solvent-free procedures in order to scale up organic synthesis is studied. The result obtained show that the strong thermal effects due to graphite/microwaves interaction can be efficiently used for the synthesis of heterocyclic molecules for which traditional methods failed or are less attractive.