Identification of proteins and signalling pathways involved in neoadjuvant chemotherapy responsiveness of breast tumours using proteomics

Abstract

A significant proportion of patients presenting with large locally advanced breast tumours, treated with neoadjuvant chemotherapy (NAC), show a poor or partial response to the treatment. The aim of this study is to identify novel phospho-proteins that may predict responsiveness to NAC treatment as there are no such biological markers available in the clinic to date.