Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp² C–H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives

Abstract

An efficient method for the synthesis of 4-aminoquinolines via palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines and isocyanides through double sp(2) C-H bonds cleavage has been developed.