Journal of Natural Products · 1986 · 91 citations · 0 references
PharmacyPharmacologyToxicologyAnalytical ToxicologyBiochemical ToxicologyMycotoxicologyInterpretation Of Toxicological FindingsMutagenicity AssessmentMycotoxin ExposureMycotoxinsToxin ProductionAlternaria MycotoxinsAlternaria ToxinsFungal ToxinsMutagenic EffectivenessMutagenic MechanismsMycotoxin ToxicologyToxic MetabolitesToxin-producing Fungi
The mold genus Alternaria is a widely distributed plant pathogen. Some of these species, e.g., A. alternata, are common decay organisms of fruits and vegetables. Two novel perylene oxide metabolites, altertoxins II and III, have been identified in extracts of A. alternata isolates that exhibit mutagenic responses in the Ames Salmonella typhimurium assay. These identifications were based on mass, optical rotational, and 1H- and 13C-nmr spectral studies. Previous reports of related perylene dione mycotoxins have been clarified.