Publication | Closed Access
Endometrial Content of Nuclear Estrogen Receptor and Receptivity for Ovoimplantation in the Rat
30
Citations
0
References
1976
Year
FertilityComparative EndocrinologyReproductive HealthNeuroendocrinologyGynecologyFemale Reproductive FunctionMenstrual CycleReproductive BiologyNuclear FractionReproductive EndocrinologyFemale InfertilityReproductive MedicineEndometrial ContentPublic HealthNuclear Estrogen ReceptorMyometrial ContractilityInfertilityMedicineHormonal ReceptorEndocrinologyOvarian HormonePlacental FunctionNuclear Binding SitesDevelopmental BiologyUterine ReceptivityPhysiologyCircadian RhythmEndocrine ResearchReproductive Hormone
The purpose of this study was to provide information concerning the amount of nuclear binding sites for estrogen in endometrial cells during the first week of pregnancy in the rat. The “insoluble” (high-salt non-extractable) binding during the first four days of pregnancy follows a circadian rhythm, with a maximal value at midnight, and a minimal one at noon. By day 5, the amount plateaus at a minimal value. The number of estradiol binding sites of the soluble (high-salt extractable) nuclear fraction shows a similar pattern. All the necessary elements for the estrogen-dependent induction of endometrial receptivity for nidation appear, therefore, to be present already by day 3, but the turningon of the endometrial response to estrogen on day 4 seems to depend on additional factor(s). (Endocrinology99: 470, 1976)