Annals of Neurology · 2005 · 250 citations · 20 references
MedicineNeurologyNeuroscienceCognitive NeurologyDementiaPsychometricsAlzheimer DiseaseCognitive ImpairmentDementia DiagnosisDementia Risk FactorsItem AnalysisSensory AssessmentAlzheimer's Disease DiagnosisMild Cognitive Impairment DiagnosisOdor Discrimination TestingOlfactory Identification TestingPreclinical Disease StagesSmell PerceptionSubjectsSubset Validation
University of Pennsylvania Smell Identification Test data from control subjects (n = 63), patients with mild cognitive impairment (n = 147), and patients with Alzheimer's disease (n = 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's disease (ie, healthy through mild cognitive impairment to early and moderate disease stages). The derived 10-item scale performed comparably with the University of Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted conversion to Alzheimer's disease on follow-up evaluation in patients with mild cognitive impairment. Independent replication is needed to validate these findings.
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Clinical diagnosis of Alzheimer's disease
Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 28K citations · Full text