<i>N</i>‐Sulfanylethylanilide Peptide as a Crypto‐Thioester Peptide

Abstract

Native chemical ligation: N-sulfanylethylanilide (SEAlide) peptides act as thioester peptides in the presence of N-terminal cysteinyl peptides and an appropriate choice of salts. With the use of the SEAlide peptide, a kinetically controlled native chemical ligation proceeding in an unprecedented highly selective manner was achieved. Additionally, a one-pot, four-component coupling under kinetic conditions was achieved. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.