(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

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Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

S. Morris Kupchan, William A. Court, Richard G. Dailey et al. · Journal of the American Chemical Society · 1972 · 510 citations

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IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

Elena B. Samoilova, Jennifer L. Horton, Brendan Hilliard et al. · The Journal of Immunology · 1998 · 442 citations · Full text

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T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

Hui Xu, Nancy A. Diiulio, Robert L. Fairchild · The Journal of Experimental Medicine · 1996 · 396 citations · Full text

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Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions.

Jeffrey D. Ohmen, Jon M. Hanifin, B J Nickoloff et al. · The Journal of Immunology · 1995 · 275 citations · Full text

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