Role of elevated monocyte transforming growth factor? (TGF?) production in posttrauma immunosuppression

Deactivation of macrophages by transforming growth factor-β

Shohko Tsunawaki, Michael B. Sporn, Aihao Ding et al. · Nature · 1988 · 870 citations

Life Sciences, Cell Biology, Immunology +9

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

Chaim O. Jacob, Zdenka Fronek, M Koo et al. · Proceedings of the National Academy of Sciences · 1990 · 632 citations

Life Sciences, Genetics, Immunology +17

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Gerald Ranges, I S Figari, Terje Espevik et al. · The Journal of Experimental Medicine · 1987 · 495 citations · Full text

Life Sciences, Cancer Biology, Immunology +17

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

Harald Renz, Jun Gong, A. Schmidt et al. · The Journal of Immunology · 1988 · 397 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Transforming growth factor- <i>beta</i> is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

Sharon M. Wahl, D A Hunt, H.L.S. Wong et al. · The Journal of Immunology · 1988 · 389 citations

Life Sciences, Cell Biology, Immunology +16