Role of elevated monocyte transforming growth factor? (TGF?) production in posttrauma immunosuppression

Deactivation of macrophages by transforming growth factor-β

Shohko Tsunawaki, Michael B. Sporn, Aihao Ding et al. · Nature · 1988 · 868 citations

Inflammation, Macrophage Biology, Growth Factor-β +7

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

Chaim O. Jacob, Zdenka Fronek, Gail D. Lewis Phillips et al. · Proceedings of the National Academy of Sciences · 1990 · 632 citations · Full text

Histocompatibility, Healthy Subjects, Genetics +19

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Gerald Ranges, I S Figari, Terje Espevik et al. · The Journal of Experimental Medicine · 1987 · 494 citations · Full text

Lymphocyte Development, T-regulatory Cell, Immunology +18

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

Harald Renz, Jun Gong, A. Schmidt et al. · The Journal of Immunology · 1988 · 397 citations · Full text

Immunology, Cell Death, Low Pge2 Concentrations +22

Transforming growth factor- <i>beta</i> is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

Sharon M. Wahl, D A Hunt, H.L.S. Wong et al. · The Journal of Immunology · 1988 · 389 citations