Concepedia

Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe

Kumar R. Bhushan, Preeti Misra, Fangbing Liu, Sanjeev Kumar Mathur, Robert E. Lenkinski, John V. Frangioni

Journal of the American Chemical Society · 2008 · 127 citations · 12 references

DOIFull text

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Concepts

Abstract

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

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