Formulation and physical properties of thixotropic gels for hard gelatin capsules

Abstract

Thixotropic gels for filling into hard gelatin capsules at room temperature were formulated using Miglyol 829 and colloidal silicon dioxide. Initial studies on several vehicles were undertaken prior to selection of Miglyol 829 for detailed study. The rheological properties of the gels and drug/gel formulations have been investigated in detail and the results are discussed with reference to capsule filling, stability and drug release of a model drug propantheline bromide (PPBr).