Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

Kevin D. Foust, Emily Nurre, Chrystal L. Montgomery et al. · Nature Biotechnology · 2008 · 1.4K citations · Full text

Medicine, Neurobiology, Neuroscience +8

Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

Anthony E. Lang, Steven S. Gill, Nikunj K. Patel et al. · Annals of Neurology · 2006 · 977 citations

Medicine, Neurology, Neuroscience +15

Functional recovery in parkinsonian monkeys treated with GDNF

Don M. Gash, Zhiming Zhang, Aliza Ovadia et al. · Nature · 1996 · 964 citations

Medicine, Neurology, Neuroscience +14

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD

John G. Nutt, Kim J. Burchiel, Cynthia Comella et al. · Neurology · 2003 · 821 citations

Life Sciences, Neurology, Neuroscience +17

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

H. Sauer, Wolfgang H. Oertel · Neuroscience · 1994 · 795 citations

Life Sciences, Neurobiology, Neuroscience +17