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Synthesis of Tricyclic Quinolones and Naphthyridones by Intramolecular Heck Cyclization of Functionalized Electron‐Rich Heterocycles
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Citations
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References
2005
Year
Diversity Oriented SynthesisDerivativesCyclized ProductsEngineeringHeterocyclicNatural SciencesIntramolecular Heck CyclizationDiversity-oriented SynthesisOrganic ChemistryFunctionalized Electron‐rich HeterocyclesMicrowave IrradiationChemistryTricyclic QuinolonesHeterocycle ChemistrySynthetic ChemistryBiomolecular Engineering
Abstract Starting from commercially available pyrrole‐ and thiophene‐2‐carboxylic acids 1 or thiophene‐ and furan‐3‐carboxylic acids 6 , we report the synthesis of tricyclic fused quinolone and naphthyridone derivatives, in only three steps, by an intramolecular Heck cyclization. We also report the use of microwave irradiation to obtain, in some cases, better yields of cyclized products. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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