PPAR-γ response element activity in intact primary human adipocytes: effects of fatty acids

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 1997 · 2.2K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Inês Barroso, Mark Gurnell, Vivion Crowley et al. · Nature · 1999 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

H. Eric Xu, Millard H. Lambert, Valerie G. Montana et al. · Molecular Cell · 1999 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Signaling +12

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

Antonio Vidal‐Puig, Robert V. Considine, Mercedes Jimenez‐Liñan et al. · Journal of Clinical Investigation · 1997 · 789 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Treatment With Dietary <i>trans</i>10<i>cis</i>12 Conjugated Linoleic Acid Causes Isomer-Specific Insulin Resistance in Obese Men With the Metabolic Syndrome

Ulf Risérus, Peter Arner, Kerstin Brismar et al. · Diabetes Care · 2002 · 436 citations · Full text

Life Sciences, Nutrition, Nutritional Sciences +17