Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591 - Concepedia

Concepedia

Publication | Open Access

Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591

DOI Full Paper Access

27

Citations

45

References

2008

Year

Sridhar Vempati, Carola Reindl, Ulla Wolf, Ruth Kern, Konstantin Petropoulos, Vegi M. Naidu, Christian Buske, Wolfgang Hiddemann, Tobias Kohl, Karsten Spiekermann

Clinical Cancer Research

Abstract

We identified two tyrosine residues, Y589 and Y591, in the juxtamembrane domain that are critical for the ligand-dependent activation of FLT3-WT and the transforming potential of oncogenic FLT3 mutants.

References

	Year	Citations

Page 1