Mechanism of Aminobisphosphonate Action: Characterization of Alendronate Inhibition of the Isoprenoid Pathway

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17

Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Ermond van Beek, Elsbet Pieterman, Louis Cohen et al. · Biochemical and Biophysical Research Communications · 1999 · 503 citations

Life Sciences, Biochemistry, Molecular Biology +6

THE BIOSYNTHESIS OF CHOLESTEROL FROM ACETATE-1-C14 BY CELLULAR FRACTIONS OF RAT LIVER

Nancy L. R. Bucher, Kathleen McGarrahan · Journal of Biological Chemistry · 1956 · 271 citations · Full text

Life Sciences, Biochemistry, Cellular Metabolism +9

Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages.

Katri S. Selander, Jukka Mönkkönen, Eeva-Kaisa Karhukorpi et al. · Molecular Pharmacology · 1996 · 239 citations

Life Sciences, Cell Biology, Pharmacology +17