Biomimetic artificial ion channels based on beta-cyclodextrin

Abstract

Star polymers based on β-cyclodextrin were synthesized by a ''click-chemistry'' process and characterized by NMR, SEC and BLM. The resulting triazole functional groups create, at a specific pH range, electrostatic hindrance between pores inserted in lipid bilayers, preventing their aggregation, allowing formation of well-defined isolated unitary pores and mimicking biological natural channels.