In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP4 receptor antagonist

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

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Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

Michihiro Mutoh, Kouji Watanabe, Tomohiro Kitamura et al. · PubMed · 2002 · 369 citations

Medicine, Oncology, Pharmacology +10

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

Jennifer M. McCoy, Joan Wicks, Laurent Audoly · Journal of Clinical Investigation · 2002 · 353 citations · Full text

Medicine, Immunology, Pharmacology +17

Prostaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor

Kiyoshi Takayama, Guillermo García‐Cardeña, Galina K. Sukhova et al. · Journal of Biological Chemistry · 2002 · 338 citations · Full text

Life Sciences, Immunology, Molecular Biology +17