2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN BRAINS OF MUTANT MICE WITH DEFICIENT MYELINATION

Abstract

Abstract —The brains of Jimpy and Quaking mice were compared with those of the corresponding normal controls during the course of development. The activity of 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase (CNP) was found to be markedly reduced in the affected animals. The reduction in the Jimpy mice was greater than in the Quaking mice. The activity of CNP seems to be proportional to that of myelin in the mutant mice. A similar reduction was found in spinal cords of the mutant mice, but there was no difference in CNP activity between the sciatic nerves of the mutant mice and those of the corresponding normal controls.