Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Medicine, Genetics, Molecular Genetics +13

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

Geoffrey W. Abbott, Federico Sesti, Igor Splawski et al. · Cell · 1999 · 1.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +17

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

Matthew C. Trudeau, Jeffrey W. Warmke, Barry Ganetzky et al. · Science · 1995 · 1.2K citations

Natural Sciences, Genetics, Molecular Genetics +17

A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 937 citations

Medicine, Cardiology, Pharmacology +17