Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147

Abstract

The expression of CypA and CD147 was significantly increased in both pancreatic cancer cell lines and tissues. Exogenous CypA promotes pancreatic cancer cell growth, which may be mediated through the interaction with CD147 and the activation of ERK1/2 and p38 MAPKs.