Organic Letters · 2011 · 110 citations · 29 references
PharmacyChemical BiologyMedicinal ChemistryDrug DiscoveryMolecular ImagingSynthetic Medicinal ChemistryCellular ImagingCombinatorial SynthesisDiversity-oriented SynthesisFluorescence ImagingFluorescence SpectroscopyMolecular Probe DevelopmentDiversity-oriented Library DesignFluorescent Probe DesignFluorescent ProbesFluorophore DesignImidazole SynthesisLive-cell ImagingLive-cell Imaging ApplicationsLive-cell Imaging Probes
A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.
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