Concepedia

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

María A. Frías, Carson C. Thoreen, Jacob D. Jaffe, Wayne A. Schroder, Tom Sculley, Steven A. Carr, David M. Sabatini

Current Biology · 2006 · 682 citations · 15 references

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15

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

Dario R. Alessi, Mirjana Andjelković, B. Caudwell et al. · The EMBO Journal · 1996 · 3K citations · Full text

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A generic protein purification method for protein complex characterization and proteome exploration

Guillaume Rigaut, Anna Shevchenko, Berthold Rutz et al. · Nature Biotechnology · 1999 · 2.7K citations

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta et al. · Molecular Cell · 2006 · 2.6K citations · Full text

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Robbie Loewith, Estela Jacinto, Stephan Wullschleger et al. · Molecular Cell · 2002 · 1.9K citations · Full text

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