Über Pterinchemie. 60. vorläufige Mitteilung [1]. Eine neue, regiospezifische Synthese von <scp>L</scp>‐Biopterin

Abstract

A new, regiospecific synthesis of L ‐biopterine Pure L ‐biopterine (I) is obtained in 35–40% yield by condensation of 5‐desoxy‐ L ‐arabinose‐hydrazone acetate with 2,4,5‐triamino‐6‐hydroxy‐pyrimidine, followed by oxidation of the formed tetrahydro‐derivative and deacetylation of the L ‐bioterine diacetate. Catalytic reduction of the L ‐biopterine gives the expected mixture of two diastereomeric tetrahydro‐ L ‐biopterines.