Chronic caffeine consumption increases the number of brain adenosine receptors

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

David R. Burt, Ian Creese, Solomon H. Snyder · Science · 1977 · 1K citations

Medicine, Neuroscience, Pharmacology +17

Tolerance to the humoral and hemodynamic effects of caffeine in man.

David Robertson, Dawn Wade, Robert J. Workman et al. · Journal of Clinical Investigation · 1981 · 506 citations · Full text

Medicine, Nutritional Sciences, Pharmacology +13

Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.

Thomas V. Dunwiddie, Thomas S. Worth · Journal of Pharmacology and Experimental Therapeutics · 1982 · 400 citations

Medicine, Neurobiology, Neurochemistry +12

Purinergic inhibition of diazepam binding to rat brain ()

P. J. Marangos, Steven M. Paul, Alexandra M. Parma et al. · Life Sciences · 1979 · 196 citations

Medicine, Neuroscience, Pharmacology +12

The tolerance of coffee drinkers to caffeine

Theodore Colton, R.E. Gosselin, Roger P. Smith · Clinical Pharmacology & Therapeutics · 1968 · 133 citations

Life Sciences, Nutritional Sciences, Physiology +11