Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex

David Kleinfeld, Partha P. Mitra, Fritjof Helmchen et al. · Proceedings of the National Academy of Sciences · 1998 · 837 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

William L. Rumsey, Jane M. Vanderkooi, David F. Wilson · Science · 1988 · 525 citations

Medicine, Biomedical Engineering, Physiology +17

Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue

Sava Sakadžić, Emmanuel Roussakis, Mohammad A. Yaseen et al. · Nature Methods · 2010 · 458 citations · Full text

Engineering, Biophysics, Neuroscience +16

Two-photon microscopy in brain tissue: parameters influencing the imaging depth

Martin Oheim, Emmanuel Beaurepaire, Emmanuelle Chaigneau et al. · Journal of Neuroscience Methods · 2001 · 416 citations

Engineering, Neurobiology, Neuroscience +16

On the fundamental imaging-depth limit in two-photon microscopy

Patrick Theer, Winfried Denk · Journal of the Optical Society of America A · 2006 · 405 citations

Natural Sciences, Biomedical Engineering, Biophysics +17