1‐Aryl‐4,6‐diamino‐1,2‐dihydro‐<i>s</i>‐triazines. Contrasting effects on intestinal helminths, bacteria, and dihydrofolic reductase

Abstract

Abstract The preparation of a variety of novel 1‐aryl‐4,6‐diamino‐1,2‐dihydro‐ s ‐triazines is described. These compounds exhibit an array of contrasting effects on intestinal helminths, bacteria, and dihydrofolic reductase. It is concluded that potent anthelmintic activity among the dihydro‐triazines is not dependent solely on the bulky‐substituent hypothesis advanced by other investigators, and indeed cannot reliably be predicted on this basis.