Robust thermoregulatory overcompensation, rather than tolerance, develops with serial administrations of 70% nitrous oxide to rats

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

Vesna Jevtović‐Todorović, S. M. Todorovć, Steven Mennerick et al. · Nature Medicine · 1998 · 679 citations

Life Sciences, Neuroscience, Pharmacology +14

Memory and the NMDA Receptors

Fēi Li, Joe Z. Tsien · New England Journal of Medicine · 2009 · 365 citations

Life Sciences, Neurobiology, Neuroscience +14

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

Karl J. Kaiyala, R L Prigeon, Steven E. Kahn et al. · Diabetes · 2000 · 319 citations · Full text

Life Sciences, Endocrinology, Neuroscience +15

Tolerance to the hyperthermic effect of morphine in the rat is a learned response.

Shepard Siegel · Journal of Comparative and Physiological Psychology · 1978 · 201 citations

Medicine, Pharmacology, Psychology +17

Pavlovian psychopharmacology: The associative basis of tolerance.

Shepard Siegel, Marco A. S. Baptista, Joseph A. Kim et al. · Experimental and Clinical Psychopharmacology · 2000 · 147 citations

Medicine, Behavioral Sciences, Pharmacology +9