The influence of nicotinic receptor subunit composition upon agonist, α–bungarotoxin and insecticide (imidacloprid) binding affinity

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

C M Flores, S W Rogers, L A Pabreza et al. · Molecular Pharmacology · 1992 · 875 citations

Life Sciences, Neuroscience, Pharmacology +17

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

Thomas F. Spande, H. Martin Garraffo, Michael W. Edwards et al. · Journal of the American Chemical Society · 1992 · 564 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

CW Luetje, James W. Patrick · Journal of Neuroscience · 1991 · 560 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Characterization and use of the<i>Drosophila</i>metallothionein promoter in cultured<i>Drosophila melanogaster</i>cells

Thomas A. Bunch, Yevgenya Grinblat, Lawrence S.B. Goldstein · Nucleic Acids Research · 1988 · 441 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

Daniel Goldman, Evan S. Deneris, Walter Luyten et al. · Cell · 1987 · 390 citations

Life Sciences, Neurobiology, Neuroscience +11