Rapid Lc–MS/MS Quantification of The Major Benzodiazepines And Their Metabolites on Dried Blood Spots Using A Simple And Cost-Effective Sample Pretreatment

Abstract

The presented strategy proved to be efficient for the rapid analysis of the selected drugs. Indeed, the offline sample preparation was reduced to a minimum, using a small amount of organic solvent and consumables, without affecting the accuracy of the method. Thus, this approach enables simple and rapid DBS analysis, even when using a non-DBS-dedicated autosampler, while lowering the costs and environmental impact.