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Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria

Toxic Porphyrin PrecursorsMedicineLiver PhysiologyPhysiologyExperimental ToxicologyToxicologyHepatotoxicityToxicological MechanismMetabolismPharmacologyMouse ModelRedox BiologyCellular PhysiologyAcute Intermittent PorphyriaPorphyriasOxidative StressHealth Sciences