The synthesis of (+)-nemorensic acid

Abstract

The synthesis of (+)-nemorensic acid in nine steps is described; key steps in the route were the stereoselective Birch reduction of a substituted furan, and addition of allyltrimethylsilane to an oxonium ion at C-5; an X-ray crystal structure of (−)-nemorensic acid provided proof of the relative stereochemistry of the target.