Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

Decline in Invasive Pneumococcal Disease after the Introduction of Protein–Polysaccharide Conjugate Vaccine

Cynthia G. Whitney, Monica M. Farley, James L. Hadler et al. · New England Journal of Medicine · 2003 · 2.2K citations · Full text

Veterinary Medicine, Infectious Disease Control, Infectious Diseases +17

Complete Genome Sequence of a Virulent Isolate of <i>Streptococcus pneumoniae</i>

Hervé Tettelin, Ian T. Paulsen, Jonathan A. Eisen et al. · Science · 2001 · 1.4K citations

Life Sciences, Genetics, Microbiology +17

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

Atsutoshi Yoshimura, Egil Lien, Robin R. Ingalls et al. · The Journal of Immunology · 1999 · 1.2K citations · Full text

Life Sciences, Immunology, Microbiology +17

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

Richard Malley, Philipp Henneke, Sarah C. Morse et al. · Proceedings of the National Academy of Sciences · 2003 · 706 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved

Nicolas W.J. Schröder, Siegfried Morath, Christian Alexander et al. · Journal of Biological Chemistry · 2003 · 636 citations · Full text

Life Sciences, Biochemistry, Immunology +17