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Elevation of Certain Plasma Proteins in Man Following Estrogen Administration: A Dose-Response Relationship
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1965
Year
Plasma CbgNeuroendocrinologyGynecologyFemale Reproductive FunctionDose-response RelationshipCertain Plasma ProteinsReproductive EndocrinologyEstrogenic Materials—premarinSteroid MetabolismGreater Cbg RiseEndocrine MechanismHormonal ReceptorAromataseEndocrinologyPharmacologyOvarian HormoneUrologyPhysiologyMenopauseMedicineEndocrine ResearchWomen's Health
The degree of elevation of the plasma concentrations of corticosteroid-binding globulin (CBG), β-glucuronidase and ceruloplasmin in response to estrogen administration was shown to be related, within limits, to the dose of estrogen. Three estrogenic materials—Premarin, diethylstilbestrol and ethinylestradiol—were tested. The highest dose-response correlation was observed with CBG and the lowest with ceruloplasmin. Ratios of potency for Premarin, diethylstilbestrol and ethinylestradiol were found to be 1:13–15:100–400, respectively. Women were found to show a significantly greater CBG rise than men after 7 days of 5 mg of diethylstilbestrol. The maximal rise of plasma CBG was found after 14 days of 5 mg of diethylstilbestrol daily. The response in 7 days was 67% of maximum.