A Long-term Study of Cerebral Vascular Disease

Abstract

Article1 September 1961A Long-term Study of Cerebral Vascular DiseaseSIGMUND N. GROCH, M.D., ELLEN MCDEVITT, M.D., IRVING S. WRIGHT, M.D., F.A.C.P.SIGMUND N. GROCH, M.D., ELLEN MCDEVITT, M.D., IRVING S. WRIGHT, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-358 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn july 1956 a long-term study of cerebral vascular disease was undertaken at Bellevue Hospital. Encouraged by the earlier writings of Fisher and Cameron (1), Millikan, Siekert, and Shick (2, 3), Denny-Brown (4), Kubik and Adams (5), Adams (6), Foley and Wright (7), and Wright and McDevitt (8), and aware of the need to establish the natural history of patients with cerebral vascular disease, the study group developed a protocol with both broad and limited objectives. This paper reports certain characteristics of a group of patients with strokes studied at a large municipal hospital. It presents a detailed analysis of...References1. FISHERCAMERON CMDG: Concerning cerebral vasospasm. Neurology 3: 468, 1953. CrossrefMedlineGoogle Scholar2. MILLIKANSIEKERTSHICK CHRGRM: Studies in cerebrovascular disease. III. The use of anticoagulant drugs in the treatment of insufficiency or thrombosis within the basilar arterial system. Proc. Mayo Clin. 30: 116, 1955. MedlineGoogle Scholar3. MILLIKANSIEKERTSHICK CHRGRM: Studies in cerebrovascular disease. V. The use of anticoagulant drugs in the treatment of intermittent insufficiency of the internal carotid arterial system. Proc. Mayo Clin. 30: 578, 1955. MedlineGoogle Scholar4. DENNY-BROWN D: The treatment of recurrent cerebrovascular symptoms and the question of "vasospasm." Med. Clin. N. Amer. 35: 1457, 1951. CrossrefMedlineGoogle Scholar5. KUBIKADAMS CSRD: Occlusion of the basilar artery—a clinical and pathological study. Brain 69: 73, 1946. CrossrefMedlineGoogle Scholar6. ADAMS RD: Mechanisms of apoplexy as determined by clinical and pathological correlation. J. Neuropath. Exp. Neurol. 13: 1, 1954. CrossrefMedlineGoogle Scholar7. FOLEYWRIGHT WTIS: The treatment of cerebral thrombosis and embolism with anticoagulant drugs. Preliminary observations. Med. Clin. N. Amer. 34: 909, 1950. CrossrefMedlineGoogle Scholar8. WRIGHTMCDEVITT ISE: Cerebral vascular diseases: their significance, diagnosis and present treatment, including the selective use of anticoagulant substances. Ann. Intern. Med. 41: 682, 1954. LinkGoogle Scholar9. MCDEVITTGROCHWRIGHT ESNIS: A cooperative study of cerebrovascular disease. Methodology and a preliminary report on the use of anticoagulants. Circulation 20: 215, 1959. CrossrefMedlineGoogle Scholar10. MCKISSOCKRICHARDSONWALSH WAL: Primary intracerebral hemorrhage. Lancet 2: 683, 1959. CrossrefGoogle Scholar11. GROCHWRIGHT SNIS: Recent trends in therapy of cerebrovascular disease. Circulation 23: 458, 1961. CrossrefMedlineGoogle Scholar12. GROCHHURWITZWRIGHTMCDOWELL SNLJISF: Intracranial lesions simulating cerebral thrombosis. J. A. M. A. 172: 1469, 1960. CrossrefMedlineGoogle Scholar13. BAKER RN, in General discussion of the Third Session, International Conference on Vascular Disease of the Brain. Neurology 11: 176, 1961. Google Scholar14. GROCH SN: The completed stroke—indications for therapy, in Cerebral Vascular Diseases. Transactions of the 3rd Princeton Conference, Jan., 1961. To be published by Grune & Stratton, Inc., New York. Google Scholar15. DALSGAARD-NIELSEN T: Some clinical experience in the treatment of cerebral apoplexy. Acta Psychiat. Scand., Supp. 108, p. 101, 1956. Google Scholar16. MILLIKANSIEKERTWHISNANT CHRGJP: Anticoagulant therapy in cerebral vascular disease; current status. J. A. M. A. 166: 578, 1958. Google Scholar17. FISHER CM: Anticoagulant therapy in cerebral thrombosis and cerebral embolism. A national cooperative study. Interim report, International Conference on Vascular Disease of the Brain. Neurology 11: 119, 1961. CrossrefMedlineGoogle Scholar18. SIEKERTMILLIKANWHISNANT RGCHJP: Anticoagulant therapy in intermittent cerebrovascular insufficiency. J. A. M. A. 176: 19, 1961. CrossrefGoogle Scholar19. CARTER AB: The immediate treatment of non-embolic hemiplegic cerebral infarction. Quart. J. Med. 28: 125, 1959. MedlineGoogle Scholar20. International Symposium on Anticoagulants and Fibrinolysins Held in Toronto, Canada, February 1-3, 1961. To be published by The Macmillan Company, Ltd., Canada. Google Scholar21. BAKER RN: An evaluation of anticoagulant therapy in the treatment of cerebrovascular disease. Report of the Veterans Administration cooperative study of atherosclerosis, Neurology Section, International Conference on Vascular Disease of the Brain. Neurology 11: 132, 1961. CrossrefMedlineGoogle Scholar22. MARSHALLSHAW JDA: Anticoagulant therapy in acute cerebrovascular accidents. Lancet 1: 995, 1960. CrossrefMedlineGoogle Scholar23. THOMES AB: Prophylactic value of anticoagulant therapy in cerebral thrombosis. Minnesota Med. 42: 1587, 1959. MedlineGoogle Scholar24. NEDERBURGH CW: Anticoagulants in the treatment of cerebrovascular occlusion in or after its acute phase. Ned. T. Geneesk. 104: 2210, 1960. MedlineGoogle Scholar25. ROBINSONCOHENHIGANOMEYERLUKOWSKYMCLAUGHLINMACGILPIN RWWDNRGHRBHH: Life-table analysis of survival after cerebral thrombosis—10-year experience. J. A. M. A. 169: 1149, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SIGMUND N. GROCH, M.D.; ELLEN MCDEVITT, M.D.; IRVING S. WRIGHT, M.D., F.A.C.P.Affiliations: New York, N. Y.Received for publication May 22, 1961.Presented at the Forty-second Annual Session of The American College of Physicians, Miami Beach, Fla., May 8-12, 1961.From the Second (Cornell) Medical and Neurological Services, Bellevue Hospital, New York N. Y., and the Department of Medicine, Cornell University College of Medicine, New York, N. Y.This study was supported by The National Institute of Neurological Diseases and Blindness, US Public Health Service Grant No. 3-B-9009.Requests for reprints should be addressed to Irving S. Wright, M.D., Professor of Clinical Medicine, Cornell University College of Medicine, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnticoagulants for acute ischaemic strokeAnticoagulants for acute ischaemic strokeAnticoagulants for preventing recurrence following presumed non-cardioembolic ischaemic stroke or transient ischaemic attackAnticoagulants for acute ischaemic strokeAnticoagulants for acute ischaemic strokeAnticoagulants for preventing recurrence following presumed non-cardioembolic ischaemic stroke or transient ischaemic attackFrequency of Major Complications of Aspirin, Warfarin, and Intravenous Heparin for Secondary Stroke Prevention: A Population-Based StudyGeorge W. Petty, MD, Robert D. Brown Jr., MD, Jack P. Whisnant, MD, JoRean D. Sicks, MS, W. Michael O'Fallon, PhD, and David O. Wiebers, MDAntithrombotic Therapy for Cerebrovascular DisordersHow often can an embolic stroke be diagnosed clinically? A clinicopathological correlationCause of cerebral infarction in the carotid territory. Its relation to the size and the location of the infarct and to the underlying vascular lesion.Differential Diagnosis of Acute Stroke: A ReviewHypertension, cerebral vascular changes and stroke in Ghana. 1—Microaneurysm formation and strokeManagement of patients with established ("completed") cerebral infarction.Current status of antithrombotic therapy in cardiovascular diseaseCerebral embolism and mitral stenosis: survival with and without anticoagulantsBrain infarction risk factors in Black New York city stroke patientsThe Contribution of Nonaneurysmal Intracranial Hemorrhage to Stroke Mortality in New York City BlacksEmbolism and microembolism in the cerebral circulationStrokes in the YoungStrokes and Carotid OcclusionCerebrovascular accidents in GhanaReferencesChanging Times and CVDThe Course of CVDCVD-Major Divisions and Subarachnoid HemorrhageCerebral Hemorrhage and ThrombosisOrale AntikoagulantienCarotid EndarterectomyThe stroke — pathogenesis, course and prognosisThe prevention of strokesECHOENCEPHALOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF CEREBRAL HÆMORRHAGE AND INFARCTIONCerebral vascular disease in relation to long-term anticoagulant therapyAnticoagulants in the Management of Various Thromboembolic DiseasesDiagnosis and Management of Extracranial and Intracranial Vascular DiseaseTherapeutic modalities in the management of cerebral vascular insufficiencySurgical and Anticoagulant Therapy of Occlusive Cerebrovascular DiseaseROBERT G. SIEKERT, M.D., F.A.C.P., JACK P. WHISNANT, M.D., CLARK H. MILLIKAN, M.D., F.A.C.PRole of anticoagulants in the treatment of cerebrovascular disease 1 September 1961Volume 55, Issue 3Page: 358-367KeywordsAnticoagulant therapyAnticoagulantsBlindnessHemorrhageHospital medicineLesionsMedical servicesStrokeThrombosisVascular diseases ePublished: 1 December 2008 Issue Published: 1 September 1961 PDF downloadLoading ...