The Nephrotic Syndrome: A Prodrome to Lymphoma

Abstract

Two patients with the nephrotic syndrome were studied: one with Hodgkin's disease and the other with lymphosarcoma. Kidney biopsy studies were made using light and electron microscopy and one by immunofluorescent microscopy. Fusion of the visceral epithelial foot processes was the common electron microscopic finding in both. Striking improvement of the nephrotic syndrome followed treatment of the primary disease. The clinical significance of the nephrotic syndrome due to lipoid nephrosis as a prodrome of lymphomas is discussed.