The Natural History of Autoimmune Disease in NZB Mice

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Article1 September 1963The Natural History of Autoimmune Disease in NZB MiceA Comparison with the Pattern of Human Autoimmune ManifestationsMARGARET C. HOLMES, PH.D., F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.MARGARET C. HOLMES, PH.D.Search for more papers by this author, F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAll mice of the NZB/Bl strain spontaneously develop serological and pathological evidence of autoimmune disease during adult life. The NZB/Bl strain was developed by Dr. Marianne Bielschowsky in Dunedin, New Zealand, by inbreeding from an outbred colony of mixed coat color. Several inbred strains—NZB, NZC, NZO, NZW, NZY, and others, have been evolved in Dunedin from the original colony. Evidence for autoimmune disease in the NZB strain was first reported by Bielschowsky, Helyer, and Howie (1) who found evidence of an autoimmune hemolytic anemia. The Dunedin group used the presence of agglutinins for ficin-treated red cells as the index of...References1. BIELSCHOWSKYHELYERHOWIE MBJJB: Proc. Univ. Otago Med. School 37: 9, 1959. Google Scholar2. HOLMESGORRIEBURNET MCJFM: Lancet ii: 638, 1961. CrossrefGoogle Scholar3. HELYERHOWIE BJJB: Proc. Univ. Otago Med. School 39: 3, 1961. Google Scholar4. NORINS L: Unpublished work, 1963. Google Scholar5. COOMBSMOURANTRACE RAAERA: Lancet I: 264, 1946. CrossrefGoogle Scholar6. LONGHOLMESBURNET GMCFM: Aust. J. Exp. Biol. Med. (in press), 1963. MedlineGoogle Scholar7. BATEMAN N: Nature 191: 271, 1961. CrossrefGoogle Scholar8. DACIE JV: The Haemolytic Anaemias: Congenital and Acquired. Part 2, 2d ed., J & A Churchill Ltd., London. Google Scholar9. BURNET FM: Aust. Ann. Med. 11: 79, 1962. MedlineGoogle Scholar10. BURNET FM: Brit. Med. J. 2: 807, 1962. CrossrefMedlineGoogle Scholar11. BURNET FM: Proceedings, Thymus Conference, Minneapolis, Minnesota (in press), 1963. Google Scholar12. BURNETHOLMES FMMC: 1963. Google Scholar13. SMITH M: Proceedings, Thymus Conference, Minneapolis, Minnesota (in press), 1963. Google Scholar14. HELYERHOWIE BJJB: Nature 197: 197, 1963. CrossrefMedlineGoogle Scholar15. WEIDENGILTINAN SP: Unpublished work, 1963. Google Scholar16. HOLMESBURNET MCFM: Aust. J. Exp. Biol. Med. (in press), 1963. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARGARET C. HOLMES, PH.D.; F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.Affiliations: Melbourne,Presented as the Lilly Lecture at the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.From The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.Request for reprints should be addressed to Sir Macfarlane Burnet, M.D., The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of the Immune System in HypertensionScientific and Regulatory Policy Committee Points-to-consider Paper*Fashioning the Immunological Self: The Biological Individuality of F. 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THEORETICAL CONSIDERATIONS AND EXPERIMENTAL DESIGN*Immunologic deficiency, autoimmune disease, and lymphoma: Observations, implications, and speculationsRenal lesions in the “auto-immune” mouse strains NZB and F1 NZB × NZWIncreased Red Cell Breakdown in Adoptively Immunized Young NZB MiceTHE THYMUS AND THE TOLERANCE FUNCTIONMYASTHENIA AS AN AUTOIMMUNE DISEASE: CLINICAL ASPECTSA NEW METHOD OF MEASURING BLOOD-PRESSURE IN MICEA New Red-Cell Autoantibody in NZB MiceTHE NATURAL HISTORY OF THE NZB/NZW F1 HYBRID MOUSE: A LABORATORY MODEL OF SYSTEMIC LUPUS ERYTHEMATOSUSTHE ROLE OF THE THYMUS IN AUTOIMMUNE DISEASEGenetic Investigations of Autoimmune Disease in MiceSpontaneous Occurrence of Autoantibodies Cytotoxic to Thymus Cells in the Sera of Mice of the 129 StrainImmunity and Systemic Lupus ErythematosusAUTOIMMUNE DISEASE IN MICE*THE STRUCTURE AND SPECIFICITY OF ERYTHROCYTE AUTOANTIBODIES*AUTOIMMUNE HEPATITIS*Mast cells in the thymus of NZB miceThymoma Associated with Erythroid Aplasia, Bullous Skin Eruption, and the Lupus Erythematosus Cell Phenomenon Report of a CaseROBERT H. KOUGH, M.D., F.A.C.P., WILLIAM T. BARNES, M.D.Systemic lupus erythematosusThe inheritance of autoimmune disease in mice: a study of hybrids of the strains NZB and C3HThymic changes in the mouse strain NZB in relation to the auto-immune stateIMMUNOLOGICAL SIGNIFICANCE OF THYMUS DELAYED SKIN REACTION IN THYMECTOMISED RATSpontaneous Autoimmunity in Mice: Antibodies to Nucleoprotein in Strain A/J 1 September 1963Volume 59, Issue 3 Page: 265-276 Keywords Autoimmune diseases Cells Hemolytic anemia ePublished: 1 December 2008 Issue Published: 1 September 1963 Copyright & PermissionsCopyright ©, 1963, by The American College of PhysiciansPDF downloadLoading ...