Organic Letters · 2009 · 33 citations · 44 references
Combinatorial ChemistryBioorganic ChemistryEngineeringOrganic ChemistryChemistryMedicinal ChemistryCross-coupling ReactionLate-stage Regio-BiochemistrySelective Alkene CouplingsNatural Product SynthesisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringConvergent SynthesisC7-c8 BondAlkene MetathesisRegioselective Asymmetric DihydroxylationNatural SciencesC8-methyl BondSynthetic Chemistry
A highly convergent synthesis of fostriecin is described, featuring sequential palladium-catalyzed Negishi cross couplings to form the C7-C8 bond and C8-methyl bond, followed by late-stage regio- and stereoselective dihydroxylation of C8-C9.
44
A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)
E. J. Corey, P.L. Fuchs · Tetrahedron Letters · 1972 · 1.6K citations
Identification of specific PP2A complexes involved in human cell transformation
Wen Chen, Richard Possemato, Katrina Campbell et al. · Cancer Cell · 2004 · 325 citations · Full text