Concepedia

An Oral Adsorbent, AST-120 Protects Against the Progression of Oxidative Stress by Reducing the Accumulation of Indoxyl Sulfate in the Systemic Circulation in Renal Failure

Kazuki Shimoishi, Makoto Anraku, Kenichiro Kitamura, Yuka Tasaki, Kazuaki Taguchi, Mitsuru Hashimoto, Eiko Fukunaga, Toru Maruyama, Masaki Otagiri

Pharmaceutical Research · 2007 · 109 citations · 27 references

DOI

Concepts

References

27

Oxidative stress and atherosclerosis

Uma Shankar Singh, Ishwarlal Jialal · Pathophysiology · 2006 · 494 citations · Full text

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Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis.

Takashi Niwa, Michihito Ise · PubMed · 1994 · 410 citations

Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity

Atsushi Enomoto, Michio Takeda, Akihiro Tojo et al. · Journal of the American Society of Nephrology · 2002 · 291 citations

Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells

Masaru Motojima, Atsuko Hosokawa, Hideyuki Yamato et al. · Kidney International · 2003 · 267 citations

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Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells

Hironori Yamamoto, Shuichi Tsuruoka, Takashi Ioka et al. · Kidney International · 2006 · 237 citations · Full text

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