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Synthesis ofN-quaternary ammonium [3H] and [99mTc]polyazamacrocycles, potential radiotracers for cartilage imaging
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2000
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EngineeringQuaternary Ammonium ChelatesBiochemistryNatural SciencesOrganic ChemistryPotential TracersSynthesis Ofn-quaternary AmmoniumBiomedical EngineeringChemistryHeterocycle ChemistryPotential RadiotracersCartilage ImagingSpecific RadioactivitySynthetic ChemistryRadiology
The [3H] and [99mTc] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [99mTc]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20–25 MBq/μmol. Copyright © 2000 John Wiley & Sons, Ltd.