Regression of Aflatoxin B <sub>1</sub> -Induced Hepatocellular Carcinomas by Reduced Glutathione

Concepts

MedicineOncologyPharmacologyCancer PharmacologyCarcinogenesisGlutathione MetabolismHepatocellular CarcinomaHepatocellular Carcinoma PharmacotherapyHepatotoxicity MechanismsLiver DiseaseMycotoxinsAblation Of Liver TumorsAflatoxin-induced Liver InjuryGlutathione In Xenobiotic MetabolismGlutathione SystemHepatotoxic MechanismsHepatotoxicity From MycotoxinsMetabolic Activation Of AflatoxinsNatural Product Chemoprevention

Abstract

Reduced glutathione administered to rats bearing aflatoxin B1-induced liver tumors caused regression of tumor growth and resulted in survival of the animals. since glutathione is a harmless natural product, it merits further investigation as a potential antitumor drug for humans.

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