Concepedia

Agonodepsides A and B:  Two New Depsides from a Filamentous Fungus F7524

Shugeng Cao, Alex S. Y. Lee, Yicun Huang, Horst Flotow, Siew Bee Ng, Mark S. Butler, Antony D. Buss

Journal of Natural Products · 2002 · 19 citations · 7 references

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Abstract

Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.

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